US scientists have created a retroviral vaccine that could teach the cells of the body to produce antibodies that neutralize HIV particles. New prick the researchers have managed to protect from AIDS laboratory mice infected with HIV.
Biologists at the California Institute of Technology in Pasadena have developed a technique vector immunization (VIP). Project manager David Baltimore in 1975 received the Nobel Prize for research into oncogenic viruses. However Baltimore colleagues studied the chemical structure of antibodies capable of neutralizing several types of viruses, including immunodeficiency. Scientists were able to insert a specially selected retrovirus "set of genetic instructions," forcing a living cell to produce antibodies.
Scientists specially cultivated population of transgenic laboratory mice whose immune system has been completely "turned off." The researchers introduced into the blood of rodents human immune cells and rodents were divided into two groups: the first was injected with the retrovirus and the second left alone. A few days after the vaccination in the first group of mice blood appeared antibodies, which have remained in the body throughout their life.
Next, the scientists tested the effectiveness of the antibodies themselves. For this purpose, they have introduced HIV particles in the blood of rodents and began to monitor the reaction of immune cells in the human appearance of the harmful virus. Each week, blood samples were taken researchers in infected mice, as well as those who were injected.
Comparing the results of the analyzes, the researchers saw that the mice with a retrovirus vaccine were completely protected from the effects of the deadly virus: pets are not lost immune cells and their bodies had been cleared of "traces" of HIV.
- The vaccine does not require any effort of the immune system, but at the moment the development of serum similar to humans remains a matter of the future. If the human body behaves like the body of the mouse, we can say with confidence that found a way to prevent the spread of the HIV virus, - commented on the success of the experiment, David Baltimore.
December 1 the whole world celebrates World AIDS Day and the opening of American biologists reassure many people suffering from the plague of the 21st century. In Russia, the spread of the disease statistics, unfortunately, disappointing. According to the management of the federal Center for Prevention and Control of AIDS in the next five years, the rate of infection in the Russian HIV doubled. Now in Russia, an estimated center are infected with HIV up to 1, 3 million people, in some regions the number exceeded 1% of the population. Russia along with Ukraine remains almost the only developed country in the world where the number of new infections is not decreasing, but increasing.
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