American scientists We discovered a gene responsible for the development shizofenii. This is an important scientific discovery It was made by the research team at Johns Hopkins University (USA).
Schizophrenia - one of the most trudnoizlechivaemyh and common mental disorders. It was known that schizophrenia has a genetic predisposition, but scientists have only recently began to discover genes "directly" responsible for the development of the heavy blemish. One such mechanism triggering schizophrenia proved gene coding for protein production CYFIP1. This gene is contained in a portion of chromosome 15q11.2.
This gene was detected as follows: the researchers took skin cells in people with schizophrenia, and using special technology converted them into stem cells. This "evolution" cells did not end - they already stem by special enzymes converted into neurons, similar grown in vitro. As a result, It revealed that neurons in violation in the area of chromosome 15q11.2 formed with lots of violations similar to those observed in the brains of schizophrenics.
That gene is found - the one the main suspect - was indirectly confirmed in experiments laboratory mice. Beast artificially reduced production of protein and CYFIP1 They observe their behavior. It turned out that the shortage CYFIP1 mice observed irregularities in the structure of the cerebral cortex and functioning neurons - and these violations were also similar to those recorded at the people suffering from schizophrenia.
Experts believe that this a big step in the process of understanding the mechanisms of schizophrenia and the search for its effective treatment. (READ MORE)
Schizophrenia - one of the most trudnoizlechivaemyh and common mental disorders. It was known that schizophrenia has a genetic predisposition, but scientists have only recently began to discover genes "directly" responsible for the development of the heavy blemish. One such mechanism triggering schizophrenia proved gene coding for protein production CYFIP1. This gene is contained in a portion of chromosome 15q11.2.
This gene was detected as follows: the researchers took skin cells in people with schizophrenia, and using special technology converted them into stem cells. This "evolution" cells did not end - they already stem by special enzymes converted into neurons, similar grown in vitro. As a result, It revealed that neurons in violation in the area of chromosome 15q11.2 formed with lots of violations similar to those observed in the brains of schizophrenics.
That gene is found - the one the main suspect - was indirectly confirmed in experiments laboratory mice. Beast artificially reduced production of protein and CYFIP1 They observe their behavior. It turned out that the shortage CYFIP1 mice observed irregularities in the structure of the cerebral cortex and functioning neurons - and these violations were also similar to those recorded at the people suffering from schizophrenia.
Experts believe that this a big step in the process of understanding the mechanisms of schizophrenia and the search for its effective treatment. (READ MORE)
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